Version 5.4
Homo sapiens Gene: ASAH2
Summary
InnateDB Gene IDBG-74349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASAH2
Gene Name N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188611
Encoded Proteins
IDBP-74446
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
IDBP-239370
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
IDBP-375984
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
IDBP-375987
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
IDBP-812094
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
IDBP-812096
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:50182778-50248610
Strand Reverse strand
Band q11.23
Transcripts
ENST00000329428 ENSP00000329886
ENST00000395526 ENSP00000378897
ENST00000447815 ENSP00000388206
ENST00000443575 ENSP00000392766
ENST00000489640 ENSP00000476827
ENST00000474434 ENSP00000476403
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017040 ceramidase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024887
View Gene Order
ENSBTAG00000003529
Not yet available
Pathways
NETPATH
REACTOME
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512645 Hs.537110
RefSeq NM_001143974 NM_019893
HUGO
OMIM
CCDS CCDS44398 CCDS7239
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca