InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: USP2

Summary

InnateDB Gene

IDBG-74471.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP2

Gene Name

ubiquitin specific peptidase 2

Synonyms

UBP41; USP9

Species

Homo sapiens

Ensembl Gene

ENSG00000036672

Encoded Proteins

IDBP-74473

ubiquitin specific peptidase 2

IDBP-384047

ubiquitin specific peptidase 2

IDBP-588007

ubiquitin specific peptidase 2

IDBP-603528

ubiquitin specific peptidase 2

IDBP-591215

ubiquitin specific peptidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25070846

USP2 deubiquitinates K63-linked polyubiquitin chains from TBK1 to terminate TBK1 activation and negatively regulate IFNB1 signalling and antiviral immune response.

Entrez Gene

Summary

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:119355215-119381726

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000260187	ENSP00000260187
ENST00000455332	ENSP00000407842
ENST00000525735	ENSP00000436952
ENST00000525189
ENST00000532613
ENST00000530918
ENST00000531070	ENSP00000433977
ENST00000527843	ENSP00000431857

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	92 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0030332	cyclin binding
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007517	muscle organ development
GO:0016579	protein deubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0045931	positive regulation of mitotic cell cycle
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0050821	protein stabilization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005938	cell cortex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032010

View Gene Order

ENSBTAG00000009749

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E9PJ34 E9PSH6

UniProt Splice Variant

Entrez Gene

9099

UniGene

Hs.524085 Hs.713219

RefSeq

NM_001243759 NM_004205 NM_171997 XM_005271721 XM_005271722

HUGO

HGNC:12618

OMIM

604725

CCDS

CCDS58189 CCDS8422 CCDS8423

HPRD

05287

IMGT

EMBL

AP003396

GenPept

RNA Seq Atlas

9099