Homo sapiens Gene: MBL2 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-74690.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | MBL2 | ||||||||||||||||||||||||||
Gene Name | mannose-binding lectin (protein C) 2, soluble | ||||||||||||||||||||||||||
Synonyms | COLEC1; HSMBPC; MBL; MBL2D; MBP; MBP-C; MBP1; MBPD | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Gene | ENSG00000165471 | ||||||||||||||||||||||||||
Encoded Proteins |
mannose-binding lectin (protein C) 2, soluble
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||
Summary |
MBL2 is a major recognition molecule of the lectin pathway of complement.
MBL2 binds directly to a wide range of repeating sugar moieties on microbial surfaces via its lectin domain, resulting in neutralization and opsonization.
MBL2 binds toll-like receptor 4 (TLR4) and modulates cellular responses by altering signals through TLRs.
MBL2 treatment inhibits the activity of NFKB and consequently suppresses the production TNF and IL12 production in human monocytes stimulated with LPS. In addition, MBL2 was found to bind to TLR4 and attenuate the binding of LPS to cell surfaces.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
Summary |
[Mus musculus] Mbl2 interacts with Fcna and fibrinogen/fibrin to augment the lectin complement pathway, which collaborates with the coagulation system in the first-line host defence against pathogens under conditions such as injury and inflammation.
[Mus musculus] Mbl2 treatment inhibits the activity of NFKB and consequently suppresses the production Tnf and Il12 production in human monocytes stimulated with LPS. In addition, Mbl2 was found to bind to Tlr4 and attenuate the binding of LPS to cell surfaces.
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Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 10:52765380-52771700 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | q21.1 | ||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Lectin pathway of complement activation pathway
Initial triggering of complement pathway
Innate Immune System pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Complement cascade pathway
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KEGG |
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
Phagosome pathway
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INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | Hs.499674 | ||||||||||||||||||||||||||
RefSeq | NM_000242 XM_006717861 | ||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS7247 | ||||||||||||||||||||||||||
HPRD | 01107 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||