InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZAK

Summary

InnateDB Gene

IDBG-75233.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZAK

Gene Name

Mitogen-activated protein kinase kinase kinase MLT

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000091436

Encoded Proteins

IDBP-75235

Mitogen-activated protein kinase kinase kinase MLT

IDBP-75237

Mitogen-activated protein kinase kinase kinase MLT

IDBP-293601

Mitogen-activated protein kinase kinase kinase MLT

IDBP-387619

Mitogen-activated protein kinase kinase kinase MLT

IDBP-588939

Mitogen-activated protein kinase kinase kinase MLT

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:173075435-173268010

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000338983	ENSP00000340257
ENST00000375213	ENSP00000364361
ENST00000409176	ENSP00000387259
ENST00000422149	ENSP00000411923
ENST00000468408
ENST00000476618
ENST00000480606
ENST00000539448	ENSP00000439414

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.

Experimentally validated
Total	49 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000077	DNA damage checkpoint
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007010	cytoskeleton organization
GO:0007050	cell cycle arrest
GO:0007257	activation of JUN kinase activity
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0009314	response to radiation
GO:0030154	cell differentiation
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004085

View Gene Order

ENSBTAG00000001083

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04530

Tight junction pathway

INOH

PID NCI

p38gammadeltapathway

Signaling mediated by p38-gamma and p38-delta

Cross-References

SwissProt

Q9NYL2

TrEMBL

B4DQ47 C9J3F7 D4Q8H0

UniProt Splice Variant

Entrez Gene

51776

UniGene

Hs.444451 Hs.713091

RefSeq

NM_016653 NM_133646 XM_005246640

HUGO

OMIM

609479

CCDS

CCDS2251 CCDS42777

HPRD

IMGT

EMBL

AB030034 AB041883 AB049733 AB049734 AB208974 AC013461 AC019046 AC092573 AF238255 AF251441 AF325454 AF465843 AF480461 AF480462 AK056310 AK298634 BC001401 CH471058

GenPept

AAF63490 AAF65822 AAH01401 AAK11615 AAL85891 AAL85892 AAO33376 AAX82002 AAX93067 BAB12040 BAB16444 BAB16445 BAD92211 BAG51674 BAG60809 BAJ05400 EAX11164

RNA Seq Atlas

51776