|Homo sapiens Gene: HOXD4|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||homeobox D4|
|Useful resources||Stemformatics EHFPI ImmGen|
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 2:176151222-176153226|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|UniGene||Hs.591609 Hs.611198 Hs.678461|
|EMBL||AK313885 BC016763 BC074797 X04706 X17360|
|GenPept||AAH16763 AAH74797 BAG36610 CAA28411 CAA35237|
|RNA Seq Atlas||3233|