Version 5.4
Homo sapiens Gene: MYPN
Summary
InnateDB Gene IDBG-75914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYPN
Gene Name myopalladin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138347
Encoded Proteins
IDBP-75916
myopalladin
IDBP-75918
myopalladin
IDBP-75922
myopalladin
IDBP-601531
myopalladin
IDBP-809335
myopalladin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:68106117-68212017
Strand Forward strand
Band q21.3
Transcripts
ENST00000358913 ENSP00000351790
ENST00000354393 ENSP00000346369
ENST00000373675 ENSP00000362779
ENST00000540630 ENSP00000441668
ENST00000613327 ENSP00000480757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0017124 SH3 domain binding
GO:0051371 muscle alpha-actinin binding
Biological Process
GO:0045214 sarcomere organization
Cellular Component
GO:0005634 nucleus
GO:0030018 Z disc
GO:0031674 I band
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020067
View Gene Order
ENSBTAG00000017509
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.612682 Hs.741064
RefSeq NM_001256267 NM_001256268 NM_032578
HUGO
OMIM
CCDS CCDS7275 CCDS73142
HPRD 10536
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca