Version 5.4
Homo sapiens Gene: BARX2
Summary
InnateDB Gene IDBG-76046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BARX2
Gene Name BARX homeobox 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000043039
Encoded Proteins
IDBP-76048
BARX homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:129375940-129452279
Strand Forward strand
Band q24.3
Transcripts
ENST00000281437 ENSP00000281437
ENST00000605151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001502 cartilage condensation
GO:0006351 transcription, DNA-templated
GO:0014902 myotube differentiation
GO:0042637 catagen
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032033
View Gene Order
ENSBTAG00000020643
Not yet available
Cross-References
SwissProt Q9UMQ3
TrEMBL G3V397
UniProt Splice Variant
Entrez Gene 8538
UniGene Hs.167218 Hs.591944 Hs.610064
RefSeq NM_003658
HUGO HGNC:956
OMIM 604823
CCDS CCDS8481
HPRD 16074
IMGT
EMBL AF031924 AF171219 AF171220 AF171221 AF171222 AJ243512 AP003775 BC069378 BC111432 BC111572 CH471065
GenPept AAC04705 AAF09453 AAH69378 AAI11433 AAI11573 CAB50736 EAW67743
RNA Seq Atlas 102725415 8538

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca