InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDX21

Summary

InnateDB Gene

IDBG-76283.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX21

Gene Name

DEAD (Asp-Glu-Ala-Asp) box helicase 21

Synonyms

GUA; GURDB; RH-II/GU; RH-II/GuA

Species

Homo sapiens

Ensembl Gene

ENSG00000165732

Encoded Proteins

IDBP-76285

DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

IDBP-811544

DEAD (Asp-Glu-Ala-Asp) box helicase 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21703541

DDX21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of DDX1, DHX36 and TICAM1, which triggers type I interferon and cytokine response to dsRNA. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21703541

[Mus musculus] Ddx21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of Ddx1, Dhx36 and Ticam1, which triggers type I interferon and cytokine response to dsRNA.

Entrez Gene

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:68956128-68985073

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000354185	ENSP00000346120
ENST00000620315	ENSP00000480334

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	118 [view]
Protein-Protein	115 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006200	ATP catabolic process
GO:0009615	response to virus
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020075

View Gene Order

ENSBTAG00000014558

Not yet available

Cross-References

SwissProt

TrEMBL

Q8NI92

UniProt Splice Variant

Entrez Gene

9188

UniGene

RefSeq

NM_001256910 NM_004728

HUGO

HGNC:2744

OMIM

606357

CCDS

CCDS73144 CCDS31211

HPRD

IMGT

EMBL

AB062394

GenPept

BAB93481

RNA Seq Atlas

9188