Homo sapiens Gene: DDX21
Summary
InnateDB Gene IDBG-76283.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX21
Gene Name DEAD (Asp-Glu-Ala-Asp) box helicase 21
Synonyms GUA; GURDB; RH-II/GU; RH-II/GuA;
Species Homo sapiens
Ensembl Gene ENSG00000165732
Encoded Proteins
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
DDX21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of DDX1, DHX36 and TICAM1, which triggers type I interferon and cytokine response to dsRNA. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Ddx21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of Ddx1, Dhx36 and Ticam1, which triggers type I interferon and cytokine response to dsRNA.
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:68956128-68985073
Strand Forward strand
Band q22.1
Transcripts
ENST00000354185 ENSP00000346120
ENST00000620315 ENSP00000480334
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 118 [view]
Protein-Protein 115 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006200 ATP catabolic process
GO:0009615 response to virus
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9NR30
TrEMBL Q8NI92
UniProt Splice Variant
Entrez Gene 9188
UniGene Hs.223141 Hs.576875 Hs.715912
RefSeq NM_004728 NM_001256910
HUGO HGNC:2744
OMIM 606357
CCDS CCDS31211 CCDS73144
HPRD 05895
IMGT
EMBL AB062394 AF261903 AF261904 AF261905 AF261906 AF261907 AF261908 AF261909 AF261910 AF261911 AF261912 AF261913 AF261914 AF261915 AF261916 AF261917 AK315585 AL359844 BC008071 CH471083 CR749598 U41387
GenPept AAB02546 AAF78930 AAH08071 BAB93481 BAG37957 CAH18395 CAH72377 EAW54307
RNA Seq Atlas 9188