|Homo sapiens Gene: DDX21|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||DEAD (Asp-Glu-Ala-Asp) box helicase 21|
|Synonyms||GUA; GURDB; RH-II/GU; RH-II/GuA;|
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
|Useful resources||Stemformatics EHFPI ImmGen|
DDX21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of DDX1, DHX36 and TICAM1, which triggers type I interferon and cytokine response to dsRNA. (Demonstrated in murine model)
|InnateDB Annotation from Orthologs|
[Mus musculus] Ddx21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of Ddx1, Dhx36 and Ticam1, which triggers type I interferon and cytokine response to dsRNA.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 10:68956128-68985073|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|UniGene||Hs.223141 Hs.576875 Hs.715912|
|EMBL||AB062394 AF261903 AF261904 AF261905 AF261906 AF261907 AF261908 AF261909 AF261910 AF261911 AF261912 AF261913 AF261914 AF261915 AF261916 AF261917 AK315585 AL359844 BC008071 CH471083 CR749598 U41387|
|GenPept||AAB02546 AAF78930 AAH08071 BAB93481 BAG37957 CAH18395 CAH72377 EAW54307|
|RNA Seq Atlas||9188|