Version 5.4
Homo sapiens Gene: FGD3
Summary
InnateDB Gene IDBG-76380.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGD3
Gene Name FYVE, RhoGEF and PH domain containing 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127084
Encoded Proteins
IDBP-76382
FYVE, RhoGEF and PH domain containing 3
IDBP-76384
FYVE, RhoGEF and PH domain containing 3
IDBP-375341
FYVE, RhoGEF and PH domain containing 3
IDBP-596977
FYVE, RhoGEF and PH domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:92947451-93036236
Strand Forward strand
Band q22.31
Transcripts
ENST00000375482 ENSP00000364631
ENST00000337352 ENSP00000336914
ENST00000416701 ENSP00000413833
ENST00000468206
ENST00000494669
ENST00000467786 ENSP00000432310
ENST00000494553
ENST00000488407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007264 small GTPase mediated signal transduction
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043088 regulation of Cdc42 GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0046847 filopodium assembly
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037946
View Gene Order
ENSBTAG00000006939
Not yet available
Pathways
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.411081
RefSeq NM_001083536 NM_001286993 NM_033086
HUGO
OMIM
CCDS CCDS43849 CCDS69619
HPRD 10957
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca