Homo sapiens Gene: CTSB | |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-7654.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | CTSB | ||||||||||||||||||||||||
Gene Name | cathepsin B | ||||||||||||||||||||||||
Synonyms | APPS; CPSB | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000164733 | ||||||||||||||||||||||||
Encoded Proteins |
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
cathepsin B
|
||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||
Summary |
CTSB is a member of the Cathepsins protein family which are key modulators of cell death and inflammatory responses.
CTSB is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. TLR2, 3, 4 ligand engagement increases the proteolytic activities of CTSB in macrophages without changing the mRNA expression or the endogenous inhibitors of CTSB. (Demonstrated in murine model)
|
||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
Summary |
[Mus musculus] Ctsb is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. Tlr2, 3, 4 ligand engagement increases the proteolytic activities of Ctsb in macrophages.
|
||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 8:11842524-11869448 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | p23.1 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||||
Pathways | |||||||||||||||||||||||||
NETPATH |
TSH pathway
|
||||||||||||||||||||||||
REACTOME |
Trafficking and processing of endosomal TLR pathway
MHC class II antigen presentation pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen degradation pathway
Extracellular matrix organization pathway
Innate Immune System pathway
Degradation of the extracellular matrix pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Immune System pathway
Collagen formation pathway
|
||||||||||||||||||||||||
KEGG |
Antigen processing and presentation pathway
Lysosome pathway
|
||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | E9PID0 E9PIS1 E9PJ67 E9PKX0 E9PL32 E9PR00 E9PR54 E9PS78 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 1508 | ||||||||||||||||||||||||
UniGene | Hs.520898 | ||||||||||||||||||||||||
RefSeq | NM_001908 NM_147780 NM_147781 NM_147782 NM_147783 XM_006716244 XM_006716245 | ||||||||||||||||||||||||
HUGO | HGNC:2527 | ||||||||||||||||||||||||
OMIM | 116810 | ||||||||||||||||||||||||
CCDS | CCDS5986 | ||||||||||||||||||||||||
HPRD | 00287 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AC025857 AC069185 | ||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | 1508 | ||||||||||||||||||||||||