InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FANCC

Summary

InnateDB Gene

IDBG-77041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FANCC

Gene Name

Fanconi anemia, complementation group C

Synonyms

FA3; FAC; FACC

Species

Homo sapiens

Ensembl Gene

ENSG00000158169

Encoded Proteins

IDBP-77043

Fanconi anemia, complementation group C

IDBP-77045

Fanconi anemia, complementation group C

IDBP-375787

Fanconi anemia, complementation group C

IDBP-812197

Fanconi anemia, complementation group C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22106009

FANCC is involved in lipopolysaccharide (LPS)-induced peritoneal macrophage inflammatory response. Fancc null mice had impaired monocyte/macrophage trafficking and cytoskeletal rearrangements following LPS treatment. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22106009

[Mus musculus] Fancc is involved in lipopolysaccharide (LPS)-induced peritoneal macrophage inflammatory response. Fancc null mice had impaired monocyte/macrophage trafficking and cytoskeletal rearrangements following LPS treatment.

Entrez Gene

Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:95099054-95317709

Strand

Reverse strand

Band

q22.32

Transcripts

ENST00000375305	ENSP00000364454
ENST00000289081	ENSP00000289081
ENST00000433829	ENSP00000406908
ENST00000464627
ENST00000480712
ENST00000477942
ENST00000490972	ENSP00000479931
ENST00000464653
ENST00000493098
ENST00000474949

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002262	myeloid cell homeostasis
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006461	protein complex assembly
GO:0007276	gamete generation
GO:0007281	germ cell development
GO:0019430	removal of superoxide radicals
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043240	Fanconi anaemia nuclear complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021461

View Gene Order

ENSBTAG00000017195

Not yet available

Pathways

NETPATH

REACTOME

REACT_18410

Fanconi Anemia pathway pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

bard1pathway

BARD1 signaling events

Cross-References

SwissProt

TrEMBL

B1ALR7 B4E3W2

UniProt Splice Variant

Entrez Gene

2176

UniGene

RefSeq

NM_001243744 NM_000136 NM_001243743

HUGO

HGNC:3584

OMIM

613899

CCDS

CCDS75861 CCDS35071

HPRD

IMGT

EMBL

AK304887 AL157384 AL354893

GenPept

BAG65624

RNA Seq Atlas

2176