Version 5.4
Homo sapiens Gene: STK4
Summary
InnateDB Gene IDBG-77184.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK4
Gene Name serine/threonine kinase 4
Synonyms KRS2; MST1; TIIAC; YSK3
Species Homo sapiens
Ensembl Gene ENSG00000101109
Encoded Proteins
IDBP-77186
serine/threonine kinase 4
IDBP-77188
serine/threonine kinase 4
IDBP-806740
serine/threonine kinase 4
IDBP-806742
serine/threonine kinase 4
IDBP-593899
serine/threonine kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it\'s possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:44966474-45079959
Strand Forward strand
Band q13.12
Transcripts
ENST00000372806 ENSP00000361892
ENST00000372801 ENSP00000361887
ENST00000488618
ENST00000480745
ENST00000487587 ENSP00000482076
ENST00000474717 ENSP00000479564
ENST00000499879 ENSP00000443514
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 106 [view]
Protein-Protein 105 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043539 protein serine/threonine kinase activator activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000902 cell morphogenesis
GO:0001569 patterning of blood vessels
GO:0001841 neural tube formation
GO:0003157 endocardium development
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0018105 peptidyl-serine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030216 keratinocyte differentiation
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0060215 primitive hemopoiesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018209
View Gene Order
ENSBTAG00000003257
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa04010
MAPK signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.472838 Hs.700137
RefSeq NM_006282 XM_005260530 XM_005260531 XM_005260532 XM_006723870
HUGO
OMIM
CCDS CCDS13341
HPRD 05395
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca