Homo sapiens Gene: SLC16A2
Summary
InnateDB Gene IDBG-77192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC16A2
Gene Name solute carrier family 16, member 2 (thyroid hormone transporter)
Synonyms AHDS; DXS128; DXS128E; MCT 7; MCT 8; MCT7; MCT8; MRX22; XPCT;
Species Homo sapiens
Ensembl Gene ENSG00000147100
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:74421461-74533917
Strand Forward strand
Band q13.2
Transcripts
ENST00000587091 ENSP00000465734
ENST00000590447 ENSP00000466213
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008028 monocarboxylic acid transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0015718 monocarboxylic acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.75317
RefSeq NM_006517
HUGO
OMIM
CCDS CCDS14426
HPRD 02106
IMGT
EMBL
GenPept
RNA Seq Atlas