Version 5.4
Homo sapiens Gene: DUSP14
Summary
InnateDB Gene IDBG-772998.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP14
Gene Name dual specificity phosphatase 14
Synonyms MKP-L; MKP6
Species Homo sapiens
Ensembl Gene ENSG00000276023
Encoded Proteins
IDBP-807277
dual specificity phosphatase 14
IDBP-807278
dual specificity phosphatase 14
IDBP-807279
dual specificity phosphatase 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:37489831-37513501
Strand Forward strand
Band q12
Transcripts
ENST00000617516 ENSP00000478595
ENST00000613659 ENSP00000484091
ENST00000614411 ENSP00000477653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
Orthologs
No orthologs found for this gene
Cross-References
SwissProt O95147
TrEMBL Q6FI36
UniProt Splice Variant
Entrez Gene 11072
UniGene
RefSeq NM_007026 XM_005256977 XM_006725300
HUGO HGNC:17007
OMIM 606618
CCDS CCDS11320
HPRD
IMGT
EMBL AF038844 AF120032 AK314894 BC000370 BC001894 BC004448 CH471199 CR536500 CR541800
GenPept AAD02105 AAF28861 AAH00370 AAH01894 AAH04448 BAG37408 CAG38739 CAG46599 EAW57592 EAW57593
RNA Seq Atlas 11072

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca