Version 5.4
Homo sapiens Gene: CCL18
Summary
InnateDB Gene IDBG-773134.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL18
Gene Name chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Synonyms AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4; PARC; SCYA18
Species Homo sapiens
Ensembl Gene ENSG00000275385
Encoded Proteins
IDBP-807400
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:36064280-36072032
Strand Forward strand
Band q12
Transcripts
ENST00000616054 ENSP00000479955
ENST00000616474
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008009 chemokine activity
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007154 cell communication
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0009607 response to biotic stimulus
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P55774
TrEMBL
UniProt Splice Variant
Entrez Gene 6362
UniGene
RefSeq NM_002988
HUGO HGNC:10616
OMIM 603757
CCDS CCDS11306
HPRD
IMGT
EMBL AB000221 AB012113 AB451458 AF082212 AF082213 AF082214 AF111198 BC069700 BC096124 BC096125 BC096126 BC096127 CH471147 CR407660 Y13710
GenPept AAC32287 AAD30390 AAH69700 AAH96124 AAH96125 AAH96126 AAH96127 BAA21670 BAA34368 BAG70272 CAA74039 CAG28588 EAW80102
RNA Seq Atlas 6362

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca