Version 5.4
Homo sapiens Gene: CCL14
Summary
InnateDB Gene IDBG-773729.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL14
Gene Name chemokine (C-C motif) ligand 14
Synonyms CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74); HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2; SY14
Species Homo sapiens
Ensembl Gene ENSG00000276409
Encoded Proteins
IDBP-808225
chemokine (C-C motif) ligand 14
IDBP-808237
chemokine (C-C motif) ligand 14
IDBP-808241
chemokine (C-C motif) ligand 14
IDBP-808251
chemokine (C-C motif) ligand 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35983291-35987004
Strand Reverse strand
Band q12
Transcripts
ENST00000614009 ENSP00000483186
ENST00000618404 ENSP00000481023
ENST00000622526 ENSP00000479097
ENST00000620991 ENSP00000484818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 11 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q16627
TrEMBL
UniProt Splice Variant
Entrez Gene 6358
UniGene
RefSeq NM_032963 NM_032962
HUGO HGNC:10612
OMIM 601392
CCDS CCDS32624 CCDS45652
HPRD
IMGT
EMBL AF088219 BC038289 BC045165 CH471147 Z49269 Z49270 Z70292 Z70293
GenPept AAC63329 AAF23982 AAH38289 AAH45165 CAA89263 CAA89264 CAA94307 CAA94309 EAW80105 EAW80106 EAW80107 EAW80108
RNA Seq Atlas 6358

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca