Version 5.4
Homo sapiens Gene: RBP3
Summary
InnateDB Gene IDBG-774254.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBP3
Gene Name retinol binding protein 3, interstitial
Synonyms D10S64; D10S65; D10S66; IRBP; RBPI; RP66
Species Homo sapiens
Ensembl Gene ENSG00000265203
Encoded Proteins
IDBP-808789
retinol binding protein 3, interstitial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38%% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:47348371-47357875
Strand Forward strand
Band q11.22
Transcripts
ENST00000584701 ENSP00000463151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005501 retinoid binding
GO:0008236 serine-type peptidase activity
GO:0016918 retinal binding
GO:0019841 retinol binding
Biological Process
GO:0001523 retinoid metabolic process
GO:0006508 proteolysis
GO:0006629 lipid metabolic process
GO:0006810 transport
GO:0007601 visual perception
GO:0007603 phototransduction, visible light
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0033165 interphotoreceptor matrix
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002900
HUGO
OMIM
CCDS CCDS73119
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca