Version 5.4
Homo sapiens Gene: SGPL1
Summary
InnateDB Gene IDBG-77509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGPL1
Gene Name sphingosine-1-phosphate lyase 1
Synonyms S1PL; SPL
Species Homo sapiens
Ensembl Gene ENSG00000166224
Encoded Proteins
IDBP-77511
sphingosine-1-phosphate lyase 1
IDBP-77513
sphingosine-1-phosphate lyase 1
IDBP-295599
sphingosine-1-phosphate lyase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:70815961-70881173
Strand Forward strand
Band q22.1
Transcripts
ENST00000299297 ENSP00000299297
ENST00000373202 ENSP00000362298
ENST00000409118 ENSP00000386549
ENST00000486993
ENST00000611290
ENST00000613857
ENST00000620724
ENST00000618021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008117 sphinganine-1-phosphate aldolase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0001553 luteinization
GO:0001570 vasculogenesis
GO:0001822 kidney development
GO:0006631 fatty acid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0007283 spermatogenesis
GO:0008152 metabolic process
GO:0008209 androgen metabolic process
GO:0008210 estrogen metabolic process
GO:0008585 female gonad development
GO:0009058 biosynthetic process
GO:0009791 post-embryonic development
GO:0010761 fibroblast migration
GO:0019752 carboxylic acid metabolic process
GO:0030097 hemopoiesis
GO:0030148 sphingolipid biosynthetic process
GO:0030149 sphingolipid catabolic process
GO:0033327 Leydig cell differentiation
GO:0040014 regulation of multicellular organism growth
GO:0044281 small molecule metabolic process
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048705 skeletal system morphogenesis
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020097
View Gene Order
ENSBTAG00000009984
Not yet available
Pathways
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
s1p_meta_pathway
Sphingosine 1-phosphate (S1P) pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.499984 Hs.598751 Hs.651967
RefSeq NM_003901 XM_005270263 XM_006718052 XM_006718053
HUGO
OMIM
CCDS CCDS31216
HPRD 07224
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca