Version 5.4
Homo sapiens Gene: HIST1H2BM
Summary
InnateDB Gene IDBG-775501.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H2BM
Gene Name histone cluster 1, H2bm
Synonyms dJ160A22.3; H2B/e; H2BFE
Species Homo sapiens
Ensembl Gene ENSG00000273703
Encoded Proteins
IDBP-810534
histone cluster 1, H2bm
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:27815044-27815424
Strand Forward strand
Band p22.1
Transcripts
ENST00000621112 ENSP00000477907
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 13 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q99879
TrEMBL I6L9F7
UniProt Splice Variant
Entrez Gene 8342
UniGene
RefSeq NM_003521
HUGO HGNC:4750
OMIM 602802
CCDS CCDS4629
HPRD
IMGT
EMBL AF531296 AL049822 BC066244 BC067485 BC067486 BC067487 BC067488 BC067489 Z83738
GenPept AAH66244 AAH67485 AAH67486 AAH67487 AAH67488 AAH67489 AAN06696 CAB06033 CAB81655
RNA Seq Atlas 8342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca