Homo sapiens Gene: MICA
Summary
InnateDB Gene IDBG-77578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MICA
Gene Name MHC class I polypeptide-related sequence A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204520
Encoded Proteins
MHC class I polypeptide-related sequence A
MHC class I polypeptide-related sequence A
MHC class I polypeptide-related sequence A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31399784-31415315
Strand Forward strand
Band p21.33
Transcripts
ENST00000449934 ENSP00000413079
ENST00000421350 ENSP00000402410
ENST00000616296 ENSP00000482382
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0045087 innate immune response
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Natural killer cell mediated cytotoxicity pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL A0A024RCL3 F5CIT5 F5CQ57 J9YLR7 L0L8F7 P78551 P79527 P79530 P79531 P79533 P79539 P79540 Q96QC4
UniProt Splice Variant
Entrez Gene 100507436
UniGene Hs.739327
RefSeq NM_001177519 NM_001289152 NM_001289153 NM_001289154
HUGO HGNC:7090
OMIM 600169
CCDS CCDS56412 CCDS75421
HPRD
IMGT
EMBL AK299135 AL645933 BA000025 CH471081 JF703686 JF766608 JX392324 JX961659 U69624 U69625 U69628 U69964 U69967 U69968 U69970 U69976 U69977
GenPept AAB51780 AAB51781 AAB51784 AAB51788 AAB51791 AAB51792 AAB51794 AAB51800 AAB51801 AEA92280 AEA92286 AFS41250 AGB57986 BAB63308 BAG61187 EAX03392 EAX03394 EAX03395 EAX03396
RNA Seq Atlas 100507436