Version 5.4
Homo sapiens Gene: CCL5
Summary
InnateDB Gene IDBG-776019.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL5
Gene Name chemokine (C-C motif) ligand 5
Synonyms D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228
Species Homo sapiens
Ensembl Gene ENSG00000271503
Encoded Proteins
IDBP-811197
chemokine (C-C motif) ligand 5
IDBP-811198
chemokine (C-C motif) ligand 5
IDBP-811200
chemokine (C-C motif) ligand 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq, Jul 2008]
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35871491-35880793
Strand Reverse strand
Band q12
Transcripts
ENST00000603197 ENSP00000474412
ENST00000605140 ENSP00000475057
ENST00000605509 ENSP00000474141
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
Experimentally validated
Total 45 [view]
Protein-Protein 32 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0016004 phospholipase activator activity
GO:0030298 receptor signaling protein tyrosine kinase activator activity
GO:0031726 CCR1 chemokine receptor binding
GO:0031729 CCR4 chemokine receptor binding
GO:0031730 CCR5 chemokine receptor binding
GO:0042056 chemoattractant activity
GO:0042379 chemokine receptor binding
GO:0042803 protein homodimerization activity
GO:0043621 protein self-association
GO:0046817 chemokine receptor antagonist activity
Biological Process
GO:0000165 MAPK cascade
GO:0002407 dendritic cell chemotaxis
GO:0002548 monocyte chemotaxis
GO:0002676 regulation of chronic inflammatory response
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006887 exocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007159 leukocyte cell-cell adhesion
GO:0007267 cell-cell signaling
GO:0009615 response to virus
GO:0009636 response to toxic substance
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010820 positive regulation of T cell chemotaxis
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0030335 positive regulation of cell migration
GO:0031328 positive regulation of cellular biosynthetic process
GO:0031584 activation of phospholipase D activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0034097 response to cytokine
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0034612 response to tumor necrosis factor
GO:0042102 positive regulation of T cell proliferation
GO:0042119 neutrophil activation
GO:0042327 positive regulation of phosphorylation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043491 protein kinase B signaling
GO:0043623 cellular protein complex assembly
GO:0043922 negative regulation by host of viral transcription
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045785 positive regulation of cell adhesion
GO:0045948 positive regulation of translational initiation
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050863 regulation of T cell activation
GO:0050918 positive chemotaxis
GO:0051262 protein tetramerization
GO:0051928 positive regulation of calcium ion transport
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070098 chemokine-mediated signaling pathway
GO:0070100 negative regulation of chemokine-mediated signaling pathway
GO:0070233 negative regulation of T cell apoptotic process
GO:0070234 positive regulation of T cell apoptotic process
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0090026 positive regulation of monocyte chemotaxis
GO:2000110 negative regulation of macrophage apoptotic process
GO:2000406 positive regulation of T cell migration
GO:2000503 positive regulation of natural killer cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P13501
TrEMBL D0EI67
UniProt Splice Variant
Entrez Gene 6352
UniGene
RefSeq NM_002985 NM_001278736
HUGO HGNC:10632
OMIM 187011
CCDS CCDS11300
HPRD
IMGT
EMBL AF043341 AF088219 AF266753 BC008600 CH471147 DQ017060 DQ230537 GQ504011 M21121
GenPept AAA36725 AAC03541 AAC63331 AAF73070 AAH08600 AAY22177 ABB69929 ACW84342 EAW80120
RNA Seq Atlas 6352

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca