Version 5.4
Homo sapiens Gene: CCL3
Summary
InnateDB Gene IDBG-776925.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL3
Gene Name chemokine (C-C motif) ligand 3
Synonyms G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
Species Homo sapiens
Ensembl Gene ENSG00000277632
Encoded Proteins
IDBP-812351
chemokine (C-C motif) ligand 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:36088256-36090169
Strand Reverse strand
Band q12
Transcripts
ENST00000613922 ENSP00000477908
ENST00000614051
ENST00000613928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 16 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0016004 phospholipase activator activity
GO:0016301 kinase activity
GO:0031726 CCR1 chemokine receptor binding
GO:0031730 CCR5 chemokine receptor binding
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0001649 osteoblast differentiation
GO:0001775 cell activation
GO:0002548 monocyte chemotaxis
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006887 exocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007010 cytoskeleton organization
GO:0007267 cell-cell signaling
GO:0007610 behavior
GO:0008360 regulation of cell shape
GO:0009636 response to toxic substance
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010818 T cell chemotaxis
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722 calcium-mediated signaling
GO:0023052 signaling
GO:0030335 positive regulation of cell migration
GO:0030502 negative regulation of bone mineralization
GO:0030593 neutrophil chemotaxis
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032760 positive regulation of tumor necrosis factor production
GO:0043085 positive regulation of catalytic activity
GO:0043308 eosinophil degranulation
GO:0043491 protein kinase B signaling
GO:0043525 positive regulation of neuron apoptotic process
GO:0043615 astrocyte cell migration
GO:0043922 negative regulation by host of viral transcription
GO:0045671 negative regulation of osteoclast differentiation
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050729 positive regulation of inflammatory response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050918 positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0051928 positive regulation of calcium ion transport
GO:0051930 regulation of sensory perception of pain
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070723 response to cholesterol
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0071621 granulocyte chemotaxis
GO:0090280 positive regulation of calcium ion import
GO:2000503 positive regulation of natural killer cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt P10147
TrEMBL A0N0R1
UniProt Splice Variant
Entrez Gene 6348
UniGene
RefSeq NM_002983
HUGO HGNC:10627
OMIM 182283
CCDS CCDS11307
HPRD
IMGT
EMBL AF043339 BC071834 BC171831 BC171891 CH471147 D00044 D90144 EF064769 M23178 M23452 M25315 X03754 X04018
GenPept AAA35858 AAA36316 AAA57255 AAC03539 AAH71834 AAI71831 AAI71891 ABK41952 BAA00029 BAA14172 CAA27388 CAA27643 EAW80100
RNA Seq Atlas 6348

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca