Homo sapiens Gene: CCL23
Summary
InnateDB Gene IDBG-777075.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL23
Gene Name chemokine (C-C motif) ligand 23
Synonyms CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a; MIP-3; MIP3; MPIF-1; SCYA23
Species Homo sapiens
Ensembl Gene ENSG00000274736
Encoded Proteins
chemokine (C-C motif) ligand 23
chemokine (C-C motif) ligand 23
chemokine (C-C motif) ligand 23
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:36013056-36017968
Strand Reverse strand
Band q12
Transcripts
ENST00000612516 ENSP00000484748
ENST00000613876 ENSP00000479076
ENST00000615050 ENSP00000481357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006955 immune response
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 6368
UniGene
RefSeq NM_145898 NM_005064
HUGO HGNC:10622
OMIM 602494
CCDS CCDS59282 CCDS11305
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 6368