Version 5.4
Homo sapiens Gene: TAF15
Summary
InnateDB Gene IDBG-777203.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAF15
Gene Name TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Synonyms Npl3; RBP56; TAF2N; TAFII68
Species Homo sapiens
Ensembl Gene ENSG00000270647
Encoded Proteins
IDBP-812739
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
IDBP-812744
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
IDBP-812751
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
IDBP-812755
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
IDBP-812758
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
IDBP-812760
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
IDBP-812765
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
IDBP-812768
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35713791-35864615
Strand Forward strand
Band q12
Transcripts
ENST00000603067
ENST00000605844 ENSP00000474096
ENST00000604879 ENSP00000475044
ENST00000604434
ENST00000603427 ENSP00000474436
ENST00000604360
ENST00000605649
ENST00000603393 ENSP00000474653
ENST00000603777 ENSP00000474522
ENST00000604841 ENSP00000474609
ENST00000605197
ENST00000603346
ENST00000604694 ENSP00000475147
ENST00000603967 ENSP00000474047
ENST00000604195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL K7EJB3
UniProt Splice Variant
Entrez Gene 8148
UniGene
RefSeq NM_003487 NM_139215
HUGO HGNC:11547
OMIM 601574
CCDS CCDS32623 CCDS59279
HPRD
IMGT
EMBL AC015849
GenPept
RNA Seq Atlas 8148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca