Homo sapiens Gene: NFKBIL1
Summary
InnateDB Gene IDBG-77826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKBIL1
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Synonyms IKBL; LST1; NFKBIL;
Species Homo sapiens
Ensembl Gene ENSG00000204498
Encoded Proteins
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31546870-31558829
Strand Forward strand
Band p21.33
Transcripts
ENST00000376148 ENSP00000365318
ENST00000376146 ENSP00000365316
ENST00000376145 ENSP00000365315
ENST00000496233 ENSP00000437148
ENST00000473655
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 25 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9UBC1
TrEMBL F2Z390 Q5STV6
UniProt Splice Variant
Entrez Gene 4795
UniGene
RefSeq NM_001144961 NM_001144962 NM_001144963 NM_005007
HUGO HGNC:7800
OMIM 601022
CCDS CCDS4700 CCDS47399 CCDS47400
HPRD
IMGT
EMBL AB000876 AB000882 AB088115 AC004181 AF097419 AF097420 AF097421 AF097422 AF097423 AF097424 AF097425 AF097426 AF097427 AF097428 AF097429 AK300818 AL662801 AL662847 AL929587 BA000025 BC143671 BX001040 BX248516 BX927320 CH471081 CR753892 CR942185 X77909 Y14768
GenPept AAD38108 AAD38109 AAD38110 AAD38111 AAD38112 AAD38113 AAD38114 AAD38115 AAD38116 AAD38117 AAD38118 AAI43672 BAB63398 BAC54951 BAG62473 CAA54867 CAA75072 CAI18289 CAI18641 CAI18643 CAI18666 CAI18667 CAI41931 CAI41933 CAQ06928 CAQ06929 CAQ07708 CAQ07709 CAQ09990 CAQ09991 EAX03417 EAX03418
RNA Seq Atlas 4795