Version 5.4
Homo sapiens Gene: NFKBIL1
Summary
InnateDB Gene IDBG-77826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKBIL1
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Synonyms IKBL; LST1; NFKBIL
Species Homo sapiens
Ensembl Gene ENSG00000204498
Encoded Proteins
IDBP-77828
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
IDBP-77832
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
IDBP-77834
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
IDBP-586745
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31546870-31558829
Strand Forward strand
Band p21.33
Transcripts
ENST00000376148 ENSP00000365318
ENST00000376146 ENSP00000365316
ENST00000376145 ENSP00000365315
ENST00000496233 ENSP00000437148
ENST00000473655
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 25 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042419
View Gene Order
ENSBTAG00000014492
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001144961 NM_001144962 NM_001144963 NM_005007
HUGO
OMIM
CCDS CCDS4700 CCDS47399 CCDS47400
HPRD 07043
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca