Homo sapiens Gene: TBX22
Summary
InnateDB Gene IDBG-78130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBX22
Gene Name T-box 22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122145
Encoded Proteins
T-box 22
T-box 22
T-box 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:80014756-80031769
Strand Forward strand
Band q21.1
Transcripts
ENST00000373296 ENSP00000362393
ENST00000373294 ENSP00000362390
ENST00000373291 ENSP00000362388
ENST00000476373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.374253
RefSeq NM_001109878 NM_001109879 NM_016954 XM_005262137 XM_005262138 XM_006725418 XM_006725420
HUGO
OMIM
CCDS CCDS14445 CCDS43975
HPRD 02253
IMGT
EMBL
GenPept
RNA Seq Atlas