Homo sapiens Gene: TBX22
Summary
InnateDB Gene IDBG-78130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBX22
Gene Name T-box 22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122145
Encoded Proteins
T-box 22
T-box 22
T-box 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:80014756-80031769
Strand Forward strand
Band q21.1
Transcripts
ENST00000373296 ENSP00000362393
ENST00000373294 ENSP00000362390
ENST00000373291 ENSP00000362388
ENST00000476373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.374253
RefSeq NM_001109878 NM_001109879 NM_016954 XM_005262137 XM_005262138 XM_006725418 XM_006725420
HUGO
OMIM
CCDS CCDS14445 CCDS43975
HPRD 02253
IMGT
EMBL
GenPept
RNA Seq Atlas