Version 5.4
Homo sapiens Gene: CLK1
Summary
InnateDB Gene IDBG-78267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLK1
Gene Name CDC-like kinase 1
Synonyms CLK; CLK/STY; STY
Species Homo sapiens
Ensembl Gene ENSG00000013441
Encoded Proteins
IDBP-78269
CDC-like kinase 1
IDBP-293195
CDC-like kinase 1
IDBP-293197
CDC-like kinase 1
IDBP-388274
CDC-like kinase 1
IDBP-388275
CDC-like kinase 1
IDBP-806918
CDC-like kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:200853009-200864744
Strand Reverse strand
Band q33.1
Transcripts
ENST00000321356 ENSP00000326830
ENST00000409403 ENSP00000386875
ENST00000409769 ENSP00000386358
ENST00000434813 ENSP00000394734
ENST00000432425 ENSP00000400487
ENST00000461981
ENST00000464454
ENST00000473565
ENST00000472679
ENST00000461326
ENST00000496205
ENST00000492793
ENST00000481641
ENST00000482590
ENST00000621181 ENSP00000479484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0008283 cell proliferation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043484 regulation of RNA splicing
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026034
View Gene Order
ENSBTAG00000005408
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.433732 Hs.624435
RefSeq NM_001162407 NM_004071
HUGO
OMIM
CCDS CCDS2331 CCDS54427
HPRD 09058
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca