Homo sapiens Gene: ALG2
Summary
InnateDB Gene IDBG-78514.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALG2
Gene Name asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119523
Encoded Proteins
asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:99216426-99221956
Strand Reverse strand
Band q22.33
Transcripts
ENST00000319033 ENSP00000326609
ENST00000238477 ENSP00000432675
ENST00000476832 ENSP00000417764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000033 alpha-1,3-mannosyltransferase activity
GO:0004378 GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
GO:0005515 protein binding
GO:0033164 glycolipid 6-alpha-mannosyltransferase activity
GO:0043495 protein anchor
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0009058 biosynthetic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0033577 protein glycosylation in endoplasmic reticulum
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051592 response to calcium ion
GO:0097502 mannosylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
KEGG
N-Glycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 85365
UniGene Hs.40919
RefSeq NM_033087
HUGO HGNC:23159
OMIM 607905
CCDS CCDS6739
HPRD 09716
IMGT
EMBL
GenPept
RNA Seq Atlas 85365