InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALG2

Summary

InnateDB Gene

IDBG-78514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALG2

Gene Name

asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000119523

Encoded Proteins

IDBP-78516

asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)

IDBP-596883

asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)

IDBP-485471

asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:99216426-99221956

Strand

Reverse strand

Band

q22.33

Transcripts

ENST00000319033	ENSP00000326609
ENST00000238477	ENSP00000432675
ENST00000476832	ENSP00000417764

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000033	alpha-1,3-mannosyltransferase activity
GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
GO:0005515	protein binding
GO:0033164	glycolipid 6-alpha-mannosyltransferase activity
GO:0043495	protein anchor
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0009058	biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0033577	protein glycosylation in endoplasmic reticulum
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0051592	response to calcium ion
GO:0097502	mannosylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039740

View Gene Order

ENSBTAG00000002454

Not yet available

Pathways

NETPATH

REACTOME

REACT_22433

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_22161

Post-translational protein modification pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.40919

RefSeq

NM_033087

HUGO

OMIM

CCDS

CCDS6739

HPRD

09716

IMGT

EMBL

GenPept

RNA Seq Atlas