Version 5.4
Homo sapiens Gene: NR4A3
Summary
InnateDB Gene IDBG-78601.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR4A3
Gene Name nuclear receptor subfamily 4, group A, member 3
Synonyms CHN; CSMF; MINOR; NOR1; TEC
Species Homo sapiens
Ensembl Gene ENSG00000119508
Encoded Proteins
IDBP-78605
nuclear receptor subfamily 4, group A, member 3
IDBP-78607
nuclear receptor subfamily 4, group A, member 3
IDBP-240247
nuclear receptor subfamily 4, group A, member 3
IDBP-810599
nuclear receptor subfamily 4, group A, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21492741
NR4A3 repressed IRF3- or IRF7-induced transactivation of the interferon-beta promoter and NDV infection further potentiated the repressive effect in dendritic cells. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21492741
[Mus musculus] Nr4a3 repressed Irf3- or Irf7-induced transactivation of the interferon-beta promoter and NDV infection further potentiated the repressive effect in dendritic cells.
Entrez Gene
Summary This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:99821855-99866891
Strand Forward strand
Band q31.1
Transcripts
ENST00000338488 ENSP00000340301
ENST00000330847 ENSP00000333122
ENST00000395097 ENSP00000378531
ENST00000618101 ENSP00000482027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 5 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004887 thyroid hormone receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001707 mesoderm formation
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007411 axon guidance
GO:0008150 biological_process
GO:0010467 gene expression
GO:0021766 hippocampus development
GO:0030522 intracellular receptor signaling pathway
GO:0030534 adult behavior
GO:0031100 organ regeneration
GO:0042472 inner ear morphogenesis
GO:0042542 response to hydrogen peroxide
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045787 positive regulation of cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048752 semicircular canal morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0060005 vestibular reflex
GO:2000108 positive regulation of leukocyte apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028341
View Gene Order
ENSBTAG00000001864
Not yet available
Cross-References
SwissProt Q92570
TrEMBL A0A024R168
UniProt Splice Variant
Entrez Gene 8013
UniGene Hs.279522 Hs.596754 Hs.736474
RefSeq NM_006981 NM_173199 NM_173200
HUGO HGNC:7982
OMIM 600542
CCDS CCDS6743 CCDS6742 CCDS6744
HPRD 02766
IMGT
EMBL AL358937 AL359710 CH471105 D78579 D85241 D85242 S81243 U12767 X89894
GenPept AAB02581 AAB36006 BAA11419 BAA28608 BAA31221 CAA61984 CAI95138 CAI95139 CAI95320 CAM16648 CAM22558 EAW58915 EAW58917 EAW58918
RNA Seq Atlas 8013

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca