Homo sapiens Gene: SEC24C
Summary
InnateDB Gene IDBG-78616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC24C
Gene Name SEC24 family, member C (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176986
Encoded Proteins
SEC24 family, member C (S. cerevisiae)
SEC24 family, member C (S. cerevisiae)
SEC24 family, member C (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:73744384-73772161
Strand Forward strand
Band q22.2
Transcripts
ENST00000339365 ENSP00000343405
ENST00000345254 ENSP00000321845
ENST00000465076 ENSP00000437000
ENST00000477008
ENST00000496827
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0048208 COPII vesicle coating
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0030127 COPII vesicle coat
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Metabolism of lipids and lipoproteins pathway
Post-translational protein modification pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
ER to Golgi Transport pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
Class I MHC mediated antigen processing & presentation pathway
Metabolism pathway
Membrane Trafficking pathway
Transport to the Golgi and subsequent modification pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P53992
TrEMBL A0A024QZM6 B4DZT4
UniProt Splice Variant
Entrez Gene 9632
UniGene Hs.81964
RefSeq NM_198597 NM_004922
HUGO HGNC:10705
OMIM 607185
CCDS CCDS7332
HPRD 06217
IMGT
EMBL AC022400 AK303085 BC018928 CH471083 D38555
GenPept AAH18928 BAA07558 BAG64196 EAW54515 EAW54517
RNA Seq Atlas 9632