InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NDST2

Summary

InnateDB Gene

IDBG-78678.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDST2

Gene Name

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000166507

Encoded Proteins

IDBP-78680

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

IDBP-78682

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

IDBP-380120

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:73801911-73811798

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000309979	ENSP00000310657
ENST00000299641	ENSP00000299641
ENST00000429742	ENSP00000392733
ENST00000463410
ENST00000465929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0016787	hydrolase activity
GO:0019213	deacetylase activity

Biological Process

GO:0002002	regulation of angiotensin levels in blood
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0008152	metabolic process
GO:0009987	cellular process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030210	heparin biosynthetic process
GO:0044281	small molecule metabolic process