Homo sapiens Gene: GRIN3A
Summary
InnateDB Gene IDBG-79119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIN3A
Gene Name glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198785
Encoded Proteins
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:101569353-101738580
Strand Reverse strand
Band q31.1
Transcripts
ENST00000361820 ENSP00000355155
ENST00000479772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0016594 glycine binding
GO:0042165 neurotransmitter binding
GO:0042802 identical protein binding
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0006810 transport
GO:0006816 calcium ion transport
GO:0016358 dendrite development
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0045471 response to ethanol
GO:0048511 rhythmic process
GO:0060134 prepulse inhibition
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8TCU5
TrEMBL
UniProt Splice Variant
Entrez Gene 116443
UniGene Hs.654783
RefSeq NM_133445
HUGO HGNC:16767
OMIM 606650
CCDS CCDS6758
HPRD
IMGT
EMBL AB075853 AF416558 AJ416950 AL356516 AL591377 BC167432
GenPept AAI67432 AAL40734 BAB85559 CAC95229 CAH69962 CAI16651
RNA Seq Atlas 116443