Homo sapiens Gene: DUSP13
Summary
InnateDB Gene IDBG-79152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP13
Gene Name dual specificity phosphatase 13
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000079393
Encoded Proteins
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
dual specificity phosphatase 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75094432-75109221
Strand Reverse strand
Band q22.2
Transcripts
ENST00000308475 ENSP00000311051
ENST00000372702 ENSP00000361787
ENST00000372700 ENSP00000361785
ENST00000394707 ENSP00000452702
ENST00000472493 ENSP00000444580
ENST00000464872 ENSP00000434041
ENST00000491677 ENSP00000436312
ENST00000478873 ENSP00000475626
ENST00000494588 ENSP00000474689
ENST00000479884 ENSP00000474298
ENST00000473072 ENSP00000475732
ENST00000605915 ENSP00000475675
ENST00000607487 ENSP00000475851
ENST00000607009
ENST00000607131 ENSP00000475801
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007126 meiotic nuclear division
GO:0007283 spermatogenesis
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q6B8I1
TrEMBL
UniProt Splice Variant
Entrez Gene 51207
UniGene
RefSeq XM_005269886 NM_016364 NM_001007271 NM_001007272 XM_005269888 XM_005269884 XM_005269887 XM_005269889
HUGO HGNC:19681
OMIM 613191
CCDS CCDS7346 CCDS53542 CCDS31224
HPRD
IMGT
EMBL AK057012 AK127886 AK291891 AK291897 AK300679 AY040091 AY674051 BC009778 CH471083
GenPept AAH09778 AAK77966 AAT79356 BAF84580 BAF84586 BAG51843 BAG54592 BAG62362 EAW54564
RNA Seq Atlas 51207