Version 5.4
Homo sapiens Gene: LSM2
Summary
InnateDB Gene IDBG-79227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSM2
Gene Name LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204392
Encoded Proteins
IDBP-79229
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31797396-31806984
Strand Reverse strand
Band p21.33
Transcripts
ENST00000375661 ENSP00000364813
ENST00000491421
ENST00000493387
ENST00000470083
ENST00000470086
ENST00000477182
ENST00000475835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 64 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007050
View Gene Order
ENSBTAG00000005634
Not yet available
Pathways
NETPATH
REACTOME
REACT_20518
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.618091
RefSeq NM_021177
HUGO
OMIM
CCDS CCDS4722
HPRD 06282
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca