Homo sapiens Gene: LSM2
Summary
InnateDB Gene IDBG-79227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSM2
Gene Name LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204392
Encoded Proteins
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31797396-31806984
Strand Reverse strand
Band p21.33
Transcripts
ENST00000375661 ENSP00000364813
ENST00000491421
ENST00000493387
ENST00000470083
ENST00000470086
ENST00000477182
ENST00000475835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 64 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA decay by 5' to 3' exoribonuclease pathway
Deadenylation-dependent mRNA decay pathway
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
RNA degradation pathway
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.618091
RefSeq NM_021177
HUGO
OMIM
CCDS CCDS4722
HPRD 06282
IMGT
EMBL
GenPept
RNA Seq Atlas