Version 5.4
Homo sapiens Gene: CREB1
Summary
InnateDB Gene IDBG-79573.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREB1
Gene Name cAMP responsive element binding protein 1
Synonyms CREB
Species Homo sapiens
Ensembl Gene ENSG00000118260
Encoded Proteins
IDBP-79577
cAMP responsive element binding protein 1
IDBP-388604
cAMP responsive element binding protein 1
IDBP-388605
cAMP responsive element binding protein 1
IDBP-388606
cAMP responsive element binding protein 1
IDBP-388607
cAMP responsive element binding protein 1
IDBP-388608
cAMP responsive element binding protein 1
IDBP-388609
cAMP responsive element binding protein 1
IDBP-388610
cAMP responsive element binding protein 1
IDBP-388611
cAMP responsive element binding protein 1
IDBP-388612
cAMP responsive element binding protein 1
IDBP-388613
cAMP responsive element binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19585511
CREB1 and AP1 transcription factor activation regulates LPS- or M-CSF-induced activation of the MAPK phosphatase-1 (MKP-1) gene, a protein phosphatase that plays a crucial role in innate immunity.
PMID 18034423
CREB1 has a key role in transcriptional regulation of macrophage migration inhibitory factor (MIF) gene expression and MIF-dependent host antimicrobial innate immune defence.
PMID 24038085
CREB1 and CEBPB are involved in cytokine production in neutrophils in response to LPS and TNF.
InnateDB Annotation from Orthologs
Summary
PMID 23405224
[Mus musculus] Creb1 over-expression in myeloid cells results in increased abscess formation and aberrant cytokine response.
Entrez Gene
Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:207529737-207603431
Strand Forward strand
Band q33.3
Transcripts
ENST00000353267 ENSP00000236995
ENST00000430624 ENSP00000405539
ENST00000432329 ENSP00000387699
ENST00000445803 ENSP00000407227
ENST00000421139 ENSP00000403678
ENST00000452474 ENSP00000392428
ENST00000414681 ENSP00000404890
ENST00000448277 ENSP00000405711
ENST00000457101 ENSP00000391125
ENST00000418081 ENSP00000412016
ENST00000455757 ENSP00000401803
ENST00000494094
ENST00000480189
ENST00000464407
ENST00000494983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 253 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 253 [view]
Protein-Protein 122 [view]
Protein-DNA 129 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0035497 cAMP response element binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007219 Notch signaling pathway
GO:0007268 synaptic transmission
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007595 lactation
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0008361 regulation of cell size
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010033 response to organic substance
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0016032 viral process
GO:0021983 pituitary gland development
GO:0030879 mammary gland development
GO:0033363 secretory granule organization
GO:0033762 response to glucagon
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0040018 positive regulation of multicellular organism growth
GO:0042493 response to drug
GO:0045087 innate immune response (InnateDB)
GO:0045600 positive regulation of fat cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046887 positive regulation of hormone secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050821 protein stabilization
GO:0051403 stress-activated MAPK cascade
GO:0060428 lung epithelium development
GO:0060430 lung saccule development
GO:0060509 Type I pneumocyte differentiation
GO:0071294 cellular response to zinc ion
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025958
View Gene Order
ENSBTAG00000005474
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_25
FSH pathway
NetPath_147
IL11 pathway
REACTOME
REACT_12442
AKT phosphorylates targets in the nucleus pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_15497
PKA-mediated phosphorylation of CREB pathway
REACT_15502
CaMK IV-mediated phosphorylation of CREB pathway
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12524
CREB phosphorylation pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_24941
Circadian Clock pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_20625
CREB phosphorylation through the activation of Adenylate Cyclase pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20661
CREB phosphorylation through the activation of CaMKK pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_13685
Neuronal System pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_15526
G-protein mediated events pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_299
Signaling by NOTCH pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_163910
NOTCH2 intracellular domain regulates transcription pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_15307
Ca-dependent events pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04612
Antigen processing and presentation pathway
hsa04710
Circadian rhythm pathway
hsa05215
Prostate cancer pathway
hsa04916
Melanogenesis pathway
hsa05016
Huntington's disease pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
ar_nongenomic_pathway
Nongenotropic Androgen signaling
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
erbb1_downstream_pathway
ErbB1 downstream signaling
atf2_pathway
ATF-2 transcription factor network
myc_represspathway
Validated targets of C-MYC transcriptional repression
lkb1_pathway
LKB1 signaling events
ilk_pathway
Integrin-linked kinase signaling
ap1_pathway
AP-1 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
ret_pathway
Signaling events regulated by Ret tyrosine kinase
lpa4_pathway
LPA4-mediated signaling events
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt
TrEMBL H7C1R5
UniProt Splice Variant
Entrez Gene 1385
UniGene Hs.516646 Hs.661542 Hs.682096 Hs.689929 Hs.714060
RefSeq NM_004379 NM_134442
HUGO HGNC:2345
OMIM 123810
CCDS CCDS2374 CCDS2375
HPRD 00442
IMGT
EMBL AC009298 AC079767
GenPept
RNA Seq Atlas 1385

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca