Version 5.4
Homo sapiens Gene: TAL2
Summary
InnateDB Gene IDBG-79714.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAL2
Gene Name T-cell acute lymphocytic leukemia 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186051
Encoded Proteins
IDBP-79718
T-cell acute lymphocytic leukemia 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:105662457-105663112
Strand Forward strand
Band q31.2
Transcripts
ENST00000334077 ENSP00000334547
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009791 post-embryonic development
GO:0021794 thalamus development
GO:0030901 midbrain development
GO:0035264 multicellular organism growth
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028417
View Gene Order
ENSBTAG00000045852
Not yet available
Cross-References
SwissProt Q16559
TrEMBL
UniProt Splice Variant
Entrez Gene 6887
UniGene Hs.247978
RefSeq NM_005421
HUGO HGNC:11557
OMIM 186855
CCDS CCDS6767
HPRD
IMGT
EMBL AL158070 BC069422 BC126373 BC126375 M81078 S69377
GenPept AAA60613 AAC60629 AAH69422 AAI26374 AAI26376 CAC22163
RNA Seq Atlas 6887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca