InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP2

Summary

InnateDB Gene

IDBG-79788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP2

Gene Name

microtubule-associated protein 2

Synonyms

MAP2A; MAP2B; MAP2C

Species

Homo sapiens

Ensembl Gene

ENSG00000078018

Encoded Proteins

IDBP-79790

microtubule-associated protein 2

IDBP-79792

microtubule-associated protein 2

IDBP-79796

microtubule-associated protein 2

IDBP-246155

microtubule-associated protein 2

IDBP-246157

microtubule-associated protein 2

IDBP-388664

microtubule-associated protein 2

IDBP-388667

microtubule-associated protein 2

IDBP-388668

microtubule-associated protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:209424058-209734118

Strand

Forward strand

Band

q34

Transcripts

ENST00000199940	ENSP00000199940
ENST00000361559	ENSP00000355290
ENST00000360351	ENSP00000353508
ENST00000392194	ENSP00000376032
ENST00000392193	ENSP00000376031
ENST00000445941	ENSP00000409969
ENST00000447185	ENSP00000392164
ENST00000452717	ENSP00000388824
ENST00000471619
ENST00000482864
ENST00000461253
ENST00000481649
ENST00000475600
ENST00000464007
ENST00000478233
ENST00000473543

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	47 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002162	dystroglycan binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding

Biological Process

GO:0001578	microtubule bundle formation
GO:0007409	axonogenesis
GO:0016358	dendrite development
GO:0021954	central nervous system neuron development
GO:0031175	neuron projection development
GO:0048813	dendrite morphogenesis
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0034399	nuclear periphery
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0044297	cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015222

View Gene Order

ENSBTAG00000018130

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

lkb1_pathway

LKB1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.368281 Hs.736133

RefSeq

NM_001039538 NM_002374 NM_031845 NM_031847 XM_005246563 XM_005246564

HUGO

OMIM

CCDS

CCDS2384 CCDS2385 CCDS33369

HPRD

01140

IMGT

EMBL

GenPept

RNA Seq Atlas