Version 5.4
Homo sapiens Gene: ERBB4
Summary
InnateDB Gene IDBG-79992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERBB4
Gene Name v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Synonyms ALS19; HER4; p180erbB4
Species Homo sapiens
Ensembl Gene ENSG00000178568
Encoded Proteins
IDBP-79994
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
IDBP-79996
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
IDBP-293096
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
IDBP-388721
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
IDBP-388722
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:211375717-212538841
Strand Reverse strand
Band q34
Transcripts
ENST00000342788 ENSP00000342235
ENST00000260943 ENSP00000260943
ENST00000402597 ENSP00000385565
ENST00000436443 ENSP00000403204
ENST00000435846 ENSP00000405564
ENST00000484594
ENST00000463121
ENST00000484474
ENST00000459774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 81 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001755 neural crest cell migration
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0007595 lactation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009880 embryonic pattern specification
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021551 central nervous system morphogenesis
GO:0021889 olfactory bulb interneuron differentiation
GO:0023014 signal transduction by phosphorylation
GO:0030334 regulation of cell migration
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066 negative regulation of apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045087 innate immune response
GO:0045165 cell fate commitment
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060644 mammary gland epithelial cell differentiation
GO:0060749 mammary gland alveolus development
GO:0061026 cardiac muscle tissue regeneration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:2000366 positive regulation of STAT protein import into nucleus
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062209
View Gene Order
ENSBTAG00000012647
Not yet available
Pathways
NETPATH
NetPath_56
Prolactin pathway
REACTOME
KEGG
hsa04012
ErbB signaling pathway pathway
hsa04020
Calcium signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
erbb4_pathway
ErbB4 signaling events
erbb_network_pathway
ErbB receptor signaling network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.390729 Hs.605364
RefSeq NM_001042599 NM_005235
HUGO
OMIM
CCDS CCDS2394 CCDS42811
HPRD 02767
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca