Version 5.4
| Homo sapiens Gene: SFTPA1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-80144.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SFTPA1 | ||||||||||||||||||
| Gene Name | surfactant protein A1 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000122852 | ||||||||||||||||||
| Encoded Proteins |
surfactant protein A1
surfactant protein A1
surfactant protein A1
surfactant protein A1
surfactant protein A1
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
SFTPA1B;SFTPA1 is a carbohydrate pattern recognition molecule of innate immunity that significantly enhances phagocytosis and killing of Aspergillus fumigatus, a pathogenic fungus, by neutrophils and macrophages.
SFTPA1B;SFTPA1 can attenuate bacterial and viral infection and inflammation by acting as an opsonin and by regulating innate immune cell functions.
SFTPA1 binds to Mycobacterium avium lipid and it promotes the agglutination of the pathogen. The presence of SFTPA1 inhibits the growth of M. avium in culture.
SPA4 peptide, derived from SFTPA1, associates with TLR4 to inhibit LPS-induced inflammation and to alleviate endotoxic shock.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 10:79610939-79615455 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q22.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Signal regulatory protein (SIRP) family interactions pathway
Cell-Cell communication pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
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| KEGG |
Phagosome pathway
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| INOH | |||||||||||||||||||
| PID NCI |
Endogenous TLR signaling
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.535295 | ||||||||||||||||||
| RefSeq | NM_001093770 NM_001164644 NM_001164645 NM_001164646 NM_001164647 NM_005411 XM_005270061 XM_005270062 XM_006717953 XM_006717954 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS44444 CCDS44445 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||