Version 5.4
Homo sapiens Gene: IGFBP5
Summary
InnateDB Gene IDBG-80733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFBP5
Gene Name insulin-like growth factor binding protein 5
Synonyms IBP5
Species Homo sapiens
Ensembl Gene ENSG00000115461
Encoded Proteins
IDBP-80735
insulin-like growth factor binding protein 5
IDBP-388837
insulin-like growth factor binding protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:216672105-216695525
Strand Reverse strand
Band q35
Transcripts
ENST00000233813 ENSP00000233813
ENST00000449583 ENSP00000413474
ENST00000486341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0031994 insulin-like growth factor I binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0006006 glucose metabolic process
GO:0007165 signal transduction
GO:0010906 regulation of glucose metabolic process
GO:0014912 negative regulation of smooth muscle cell migration
GO:0017148 negative regulation of translation
GO:0030336 negative regulation of cell migration
GO:0031069 hair follicle morphogenesis
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0042593 glucose homeostasis
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0044267 cellular protein metabolic process
GO:0044342 type B pancreatic cell proliferation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048630 skeletal muscle tissue growth
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051146 striated muscle cell differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060056 mammary gland involution
GO:0071320 cellular response to cAMP
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005576 extracellular region
GO:0016942 insulin-like growth factor binding protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026185
View Gene Order
ENSBTAG00000007062
Not yet available
Pathways
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
INOH website
IGF1 signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL C9JXX4
UniProt Splice Variant
Entrez Gene 3488
UniGene Hs.599281 Hs.607212 Hs.613148 Hs.703866 Hs.707329 Hs.715157
RefSeq NM_000599
HUGO HGNC:5474
OMIM 146734
CCDS CCDS2405
HPRD 00901
IMGT
EMBL AC007563
GenPept
RNA Seq Atlas 3488

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca