Homo sapiens Gene: CXCR2
Summary
InnateDB Gene IDBG-80804.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCR2
Gene Name chemokine (C-X-C motif) receptor 2
Synonyms CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB;
Species Homo sapiens
Ensembl Gene ENSG00000180871
Encoded Proteins
chemokine (C-X-C motif) receptor 2
chemokine (C-X-C motif) receptor 2
chemokine (C-X-C motif) receptor 2
chemokine (C-X-C motif) receptor 2
chemokine (C-X-C motif) receptor 2
chemokine (C-X-C motif) receptor 2
chemokine (C-X-C motif) receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL8RB is a G protein-coupled receptor that mediates NADPH oxidase-independent neutrophil extracellular trap (NET) formation and this G protein-coupled receptor (GPCR) pathway is operative and drug-sensitive in cystic fibrosis lung disease.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
[Mus musculus] Fibrates protect against bacteria�induced sepsis by inhibiting LPS�mediated ERK phosphorylation and the expression of Adrbk1 (GRK2), thereby preventing Cxcr2 down-regulation on neutrophils.
Entrez Gene
Summary The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:218125289-218137253
Strand Forward strand
Band q35
Transcripts
ENST00000318507 ENSP00000319635
ENST00000453237 ENSP00000413686
ENST00000415392 ENSP00000392348
ENST00000449014 ENSP00000410506
ENST00000454148 ENSP00000415148
ENST00000428565 ENSP00000392698
ENST00000418878 ENSP00000416815
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004918 interleukin-8 receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016494 C-X-C chemokine receptor activity
GO:0019959 interleukin-8 binding
Biological Process
GO:0002407 dendritic cell chemotaxis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0030593 neutrophil chemotaxis
GO:0031623 receptor internalization
GO:0038112 interleukin-8-mediated signaling pathway
GO:0042119 neutrophil activation
GO:0045087 innate immune response (InnateDB)
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
Endocytosis pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
GPCR signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
PID NCI
IL8- and CXCR2-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.846
RefSeq NM_001168298 NM_001557 XM_005246530 XM_005246531
HUGO
OMIM
CCDS CCDS2408
HPRD 00907
IMGT
EMBL
GenPept
RNA Seq Atlas