InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCR2

Summary

InnateDB Gene

IDBG-80804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR2

Gene Name

chemokine (C-X-C motif) receptor 2

Synonyms

CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB

Species

Homo sapiens

Ensembl Gene

ENSG00000180871

Encoded Proteins

IDBP-80806

chemokine (C-X-C motif) receptor 2

IDBP-388853

chemokine (C-X-C motif) receptor 2

IDBP-388854

chemokine (C-X-C motif) receptor 2

IDBP-388855

chemokine (C-X-C motif) receptor 2

IDBP-388856

chemokine (C-X-C motif) receptor 2

IDBP-388857

chemokine (C-X-C motif) receptor 2

IDBP-388858

chemokine (C-X-C motif) receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20818377

IL8RB is a G protein-coupled receptor that mediates NADPH oxidase-independent neutrophil extracellular trap (NET) formation and this G protein-coupled receptor (GPCR) pathway is operative and drug-sensitive in cystic fibrosis lung disease.

InnateDB Annotation from Orthologs

Summary

PMID 24651866

[Mus musculus] In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.

PMID 24755316

[Mus musculus] Fibrates protect against bacteria�?�induced sepsis by inhibiting LPS�?�mediated ERK phosphorylation and the expression of Adrbk1 (GRK2), thereby preventing Cxcr2 down-regulation on neutrophils.

Entrez Gene

Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:218125289-218137253

Strand

Forward strand

Band

q35

Transcripts

ENST00000318507	ENSP00000319635
ENST00000453237	ENSP00000413686
ENST00000415392	ENSP00000392348
ENST00000449014	ENSP00000410506
ENST00000454148	ENSP00000415148
ENST00000428565	ENSP00000392698
ENST00000418878	ENSP00000416815

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004918	interleukin-8 receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016494	C-X-C chemokine receptor activity
GO:0019959	interleukin-8 binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0030593	neutrophil chemotaxis
GO:0031623	receptor internalization
GO:0038112	interleukin-8-mediated signaling pathway
GO:0042119	neutrophil activation
GO:0045087	innate immune response (InnateDB)
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042629	mast cell granule