Version 5.4
Homo sapiens Gene: ESX1
Summary
InnateDB Gene IDBG-80974.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESX1
Gene Name ESX homeobox 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123576
Encoded Proteins
IDBP-80976
ESX homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:104250038-104254933
Strand Reverse strand
Band q22.2
Transcripts
ENST00000372588 ENSP00000361669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 4 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051726 regulation of cell cycle
GO:0060713 labyrinthine layer morphogenesis
GO:0060716 labyrinthine layer blood vessel development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q8N693
TrEMBL A6ZIT2 A6ZIU4
UniProt Splice Variant
Entrez Gene 80712
UniGene Hs.223782
RefSeq NM_153448
HUGO HGNC:14865
OMIM 300154
CCDS CCDS14516
HPRD 08945
IMGT
EMBL AL049631 AY114148 BC042633 BC053599 CH471120 EF695424 EF695436
GenPept AAH42633 AAH53599 AAM62141 ABS01462 ABS01474 CAQ08095 EAX02755
RNA Seq Atlas 80712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca