Homo sapiens Gene: MMRN2
Summary
InnateDB Gene IDBG-81133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMRN2
Gene Name multimerin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173269
Encoded Proteins
multimerin 2
multimerin 2
multimerin 2
multimerin 2
multimerin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:86935540-86969481
Strand Reverse strand
Band q23.2
Transcripts
ENST00000372027 ENSP00000361097
ENST00000488950
ENST00000474994 ENSP00000473405
ENST00000610081 ENSP00000477052
ENST00000609457 ENSP00000476378
ENST00000608090 ENSP00000476355
ENST00000608753
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
Cellular Component
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_024756 XM_005270153
HUGO
OMIM
CCDS CCDS7379
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas