Version 5.4
Homo sapiens Gene: MMRN2
Summary
InnateDB Gene IDBG-81133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMRN2
Gene Name multimerin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173269
Encoded Proteins
IDBP-81135
multimerin 2
IDBP-812356
multimerin 2
IDBP-812350
multimerin 2
IDBP-812353
multimerin 2
IDBP-812360
multimerin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:86935540-86969481
Strand Reverse strand
Band q23.2
Transcripts
ENST00000372027 ENSP00000361097
ENST00000488950
ENST00000474994 ENSP00000473405
ENST00000610081 ENSP00000477052
ENST00000609457 ENSP00000476378
ENST00000608090 ENSP00000476355
ENST00000608753
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
Cellular Component
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041445
View Gene Order
ENSBTAG00000003510
Not yet available
Cross-References
SwissProt
TrEMBL V9GY37
UniProt Splice Variant
Entrez Gene 79812
UniGene
RefSeq NM_024756 XM_005270153
HUGO HGNC:19888
OMIM 608925
CCDS CCDS7379
HPRD
IMGT
EMBL AC025268 AL136982
GenPept
RNA Seq Atlas 79812

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca