InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT10A

Summary

InnateDB Gene

IDBG-81200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT10A

Gene Name

wingless-type MMTV integration site family, member 10A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000135925

Encoded Proteins

IDBP-81202

wingless-type MMTV integration site family, member 10A

IDBP-388973

wingless-type MMTV integration site family, member 10A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:218880363-218899581

Strand

Forward strand

Band

q35

Transcripts

ENST00000258411	ENSP00000258411
ENST00000458582	ENSP00000388812
ENST00000483911
ENST00000489887

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0001942	hair follicle development
GO:0007275	multicellular organismal development
GO:0010628	positive regulation of gene expression
GO:0014033	neural crest cell differentiation
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0031069	hair follicle morphogenesis
GO:0042476	odontogenesis
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0043586	tongue development
GO:0043588	skin development
GO:0045165	cell fate commitment
GO:0048730	epidermis morphogenesis
GO:0048733	sebaceous gland development
GO:0071560	cellular response to transforming growth factor beta stimulus