Version 5.4
Homo sapiens Gene: PTEN
Summary
InnateDB Gene IDBG-81409.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTEN
Gene Name phosphatase and tensin homolog
Synonyms 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Species Homo sapiens
Ensembl Gene ENSG00000171862
Encoded Proteins
IDBP-81411
phosphatase and tensin homolog
IDBP-810073
phosphatase and tensin homolog
IDBP-810075
phosphatase and tensin homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25015834
PI3K/PTEN-regulated extracellular ARG1 acts as a paracrine regulator of inflammation and immunity. Demonstrated in mice.
InnateDB Annotation from Orthologs
Summary
PMID 25646418
[Mus musculus] Pten is an essential regulator of natural killer cell localization in vivo during both homeostasis and malignancy.
Entrez Gene
Summary This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:87863113-87971930
Strand Forward strand
Band q23.31
Transcripts
ENST00000371953 ENSP00000361021
ENST00000487939
ENST00000462694
ENST00000498703
ENST00000472832 ENSP00000483066
ENST00000618586
ENST00000610634 ENSP00000477517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 139 [view]
Protein-Protein 135 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008289 lipid binding
GO:0010997 anaphase-promoting complex binding
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016791 phosphatase activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0002902 regulation of B cell apoptotic process
GO:0006470 protein dephosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006915 apoptotic process
GO:0007092 activation of mitotic anaphase-promoting complex activity
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007270 neuron-neuron synaptic transmission
GO:0007416 synapse assembly
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007611 learning or memory
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010035 response to inorganic substance
GO:0010043 response to zinc ion
GO:0010975 regulation of neuron projection development
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014070 response to organic cyclic compound
GO:0016311 dephosphorylation
GO:0016477 cell migration
GO:0021542 dentate gyrus development
GO:0021955 central nervous system neuron axonogenesis
GO:0030336 negative regulation of cell migration
GO:0031175 neuron projection development
GO:0031642 negative regulation of myelination
GO:0031647 regulation of protein stability
GO:0031658 negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032286 central nervous system myelin maintenance
GO:0032355 response to estradiol
GO:0032535 regulation of cellular component size
GO:0033032 regulation of myeloid cell apoptotic process
GO:0033198 response to ATP
GO:0033555 multicellular organismal response to stress
GO:0035176 social behavior
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0042711 maternal behavior
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043491 protein kinase B signaling
GO:0043542 endothelial cell migration
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045475 locomotor rhythm
GO:0045792 negative regulation of cell size
GO:0046621 negative regulation of organ growth
GO:0046685 response to arsenic-containing substance
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048738 cardiac muscle tissue development
GO:0048853 forebrain morphogenesis
GO:0048854 brain morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050765 negative regulation of phagocytosis
GO:0050771 negative regulation of axonogenesis
GO:0050821 protein stabilization
GO:0050852 T cell receptor signaling pathway
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726 regulation of cell cycle
GO:0051895 negative regulation of focal adhesion assembly
GO:0051898 negative regulation of protein kinase B signaling
GO:0060024 rhythmic synaptic transmission
GO:0060070 canonical Wnt signaling pathway
GO:0060074 synapse maturation
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
GO:0060291 long-term synaptic potentiation
GO:0060292 long term synaptic depression
GO:0060736 prostate gland growth
GO:0060997 dendritic spine morphogenesis
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0090071 negative regulation of ribosome biogenesis
GO:0090344 negative regulation of cell aging
GO:0090394 negative regulation of excitatory postsynaptic membrane potential
GO:0097105 presynaptic membrane assembly
GO:0097107 postsynaptic density assembly
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
GO:2000808 negative regulation of synaptic vesicle clustering
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0016605 PML body
GO:0035749 myelin sheath adaxonal region
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0043220 Schmidt-Lanterman incisure
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013663
View Gene Order
ENSBTAG00000009498
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_22
Leptin pathway
REACTOME
REACT_12447
Negative regulation of the PI3K/AKT network pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12555
Downstream TCR signaling pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_12526
TCR signaling pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa00562
Inositol phosphate metabolism pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04530
Tight junction pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04115
p53 signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
Inositol phosphate metabolism pathway
PID NCI
pi3kcipathway
Class I PI3K signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
p53downstreampathway
Direct p53 effectors
ap1_pathway
AP-1 transcription factor network
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
rhoa_pathway
RhoA signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.500466 Hs.600528 Hs.606086 Hs.644684 Hs.705847 Hs.706095 Hs.717458
RefSeq NM_000314
HUGO
OMIM
CCDS CCDS31238
HPRD 03431
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca