InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL3

Summary

InnateDB Gene

IDBG-8149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL3

Gene Name

ribosomal protein L3

Synonyms

ASC-1; L3; TARBP-B

Species

Homo sapiens

Ensembl Gene

ENSG00000100316

Encoded Proteins

IDBP-8155

ribosomal protein L3

IDBP-293439

ribosomal protein L3

IDBP-293437

ribosomal protein L3

IDBP-377214

ribosomal protein L3

IDBP-377216

ribosomal protein L3

IDBP-377218

ribosomal protein L3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Intronic regions of ribosomal protein genes can harbor noncoding small nucleolar RNAs (snoRNAs), like SNORD83B, which are generated during pre-mRNA processing. snoRNAs form part of the small nucleolar ribonucleoprotein particles (snoRNPs) involved in pre-rRNA processing and modification. snoRNAs of the box C/D class, like SNORD83B, function in 2-prime-O-ribose methylation of rRNAs (Duga et al., 2000 [PubMed 10684968]).[supplied by OMIM, Mar 2008] Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] Intronic regions of ribosomal protein genes can harbor noncoding small nucleolar RNAs (snoRNAs), like U86, which are generated during pre-mRNA processing. snoRNAs form part of the small nucleolar ribonucleoprotein particles (snoRNPs) involved in pre-rRNA processing and modification. snoRNAs of the box C/D class, like U86, function in 2-prime-O-ribose methylation of rRNAs (Duga et al., 2000 [PubMed 10684968]).[supplied by OMIM, Mar 2008]
Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene\'s introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:39312882-39320389

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000216146	ENSP00000346001
ENST00000401609	ENSP00000386101
ENST00000402527	ENSP00000385762
ENST00000453303	ENSP00000415198
ENST00000427905	ENSP00000412713
ENST00000420536	ENSP00000416273
ENST00000465618
ENST00000473638
ENST00000464182
ENST00000467105
ENST00000481985
ENST00000471290
ENST00000484358
ENST00000484615
ENST00000460589
ENST00000461967
ENST00000498462
ENST00000459859

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	115 [view]
Protein-Protein	113 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0070062	extracellular vesicular exosome