Version 5.4
Homo sapiens Gene: TSC22D3
Summary
InnateDB Gene IDBG-81583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSC22D3
Gene Name TSC22 domain family, member 3
Synonyms DIP; DSIPI; GILZ; hDIP; TSC-22R
Species Homo sapiens
Ensembl Gene ENSG00000157514
Encoded Proteins
IDBP-81585
TSC22 domain family, member 3
IDBP-81587
TSC22 domain family, member 3
IDBP-81591
TSC22 domain family, member 3
IDBP-81593
TSC22 domain family, member 3
IDBP-81595
TSC22 domain family, member 3
IDBP-81597
TSC22 domain family, member 3
IDBP-483480
TSC22 domain family, member 3
IDBP-484965
TSC22 domain family, member 3
IDBP-483472
TSC22 domain family, member 3
IDBP-474322
TSC22 domain family, member 3
IDBP-483695
TSC22 domain family, member 3
IDBP-482008
TSC22 domain family, member 3
IDBP-481831
TSC22 domain family, member 3
IDBP-473905
TSC22 domain family, member 3
IDBP-474831
TSC22 domain family, member 3
IDBP-479725
TSC22 domain family, member 3
IDBP-475716
TSC22 domain family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22539300
TSC22D3 is downregulated following TLR activation in macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 22539300
[Mus musculus] Tsc22d3 is downregulated following TLR activation in macrophages.
Entrez Gene
Summary The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:107713221-107777342
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372397 ENSP00000361474
ENST00000372390 ENSP00000361466
ENST00000372384 ENSP00000361459
ENST00000372383 ENSP00000361458
ENST00000372382 ENSP00000361457
ENST00000315660 ENSP00000314655
ENST00000506081 ENSP00000427427
ENST00000514426 ENSP00000421016
ENST00000486554 ENSP00000425414
ENST00000503515 ENSP00000422060
ENST00000514897 ENSP00000427199
ENST00000480691 ENSP00000425155
ENST00000510887 ENSP00000422636
ENST00000502650 ENSP00000424653
ENST00000506724 ENSP00000427075
ENST00000505965 ENSP00000425158
ENST00000502961 ENSP00000422228
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 31 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043426 MRF binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006970 response to osmotic stress
GO:0007589 body fluid secretion
GO:0034220 ion transmembrane transport
GO:0045087 innate immune response (InnateDB)
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0055085 transmembrane transport
GO:0070236 negative regulation of activation-induced cell death of T cells
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031431
View Gene Order
ENSBTAG00000045877
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6R8Z7
UniProt Splice Variant
Entrez Gene 1831
UniGene Hs.735705 Hs.741199
RefSeq NM_001015881 NM_004089 NM_198057 XM_005262098 XM_005262099 XM_005262100 XM_005262101 XM_005262102 XM_005262103 XM_006724629
HUGO HGNC:3051
OMIM 300506
CCDS CCDS14530 CCDS14531 CCDS35365
HPRD 04266
IMGT
EMBL AL590423
GenPept
RNA Seq Atlas 1831

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca