Homo sapiens Gene: GMPPA
Summary
InnateDB Gene IDBG-81790.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMPPA
Gene Name GDP-mannose pyrophosphorylase A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144591
Encoded Proteins
GDP-mannose pyrophosphorylase A
GDP-mannose pyrophosphorylase A
GDP-mannose pyrophosphorylase A
GDP-mannose pyrophosphorylase A
GDP-mannose pyrophosphorylase A
GDP-mannose pyrophosphorylase A
GDP-mannose pyrophosphorylase A
GDP-mannose pyrophosphorylase A
GDP-mannose pyrophosphorylase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:219498867-219506988
Strand Forward strand
Band q35
Transcripts
ENST00000373917 ENSP00000363027
ENST00000313597 ENSP00000315925
ENST00000358215 ENSP00000350949
ENST00000373908 ENSP00000363016
ENST00000341142 ENSP00000340760
ENST00000443704 ENSP00000396750
ENST00000455657 ENSP00000392465
ENST00000435316 ENSP00000411060
ENST00000480506
ENST00000481170
ENST00000480034
ENST00000496536
ENST00000622191 ENSP00000478700
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0009058 biosynthetic process
GO:0009298 GDP-mannose biosynthetic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Asparagine N-linked glycosylation pathway
Synthesis of GDP-mannose pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
KEGG
Fructose and mannose metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
INOH
Fructose Mannose metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9J255
UniProt Splice Variant
Entrez Gene 29926
UniGene Hs.27059
RefSeq NM_013335 NM_205847 XM_005246483 XM_005246485 XM_005246486 XM_005246487
HUGO HGNC:22923
OMIM 615495
CCDS CCDS2441
HPRD 13588
IMGT
EMBL AC053503
GenPept
RNA Seq Atlas 29926