Version 5.4
Homo sapiens Gene: IFIT3
Summary
InnateDB Gene IDBG-81919.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFIT3
Gene Name interferon-induced protein with tetratricopeptide repeats 3
Synonyms CIG-49; GARG-49; IFI60; IFIT4; IRG2; ISG60; P60; RIG-G
Species Homo sapiens
Ensembl Gene ENSG00000119917
Encoded Proteins
IDBP-81921
interferon-induced protein with tetratricopeptide repeats 3
IDBP-81923
interferon-induced protein with tetratricopeptide repeats 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21813773
IFIT3 triggers host antiviral responses by bridging TBK1 to MAVS, and IFIT3 plays an important role in the activation of IRF3.
PMID 27210312
Hepatitis B virus-induced MIR146A attenuates cell-intrinsic anti-viral innate immunity through targeting DDX58 and IFIT3.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:89327894-89340971
Strand Forward strand
Band q23.31
Transcripts
ENST00000371818 ENSP00000360883
ENST00000371811 ENSP00000360876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
Experimentally validated
Total 67 [view]
Protein-Protein 65 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0035457 cellular response to interferon-alpha
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O14879
TrEMBL B4DLS7 Q5T765
UniProt Splice Variant
Entrez Gene 3437
UniGene Hs.47338
RefSeq NM_001289758 NM_001289759 NM_001549 NM_001031683
HUGO HGNC:5411
OMIM 604650
CCDS CCDS7402 CCDS31241
HPRD 05228
IMGT
EMBL AF026939 AF083470 AK290427 AK297137 BC001383 BC004977 BT007284 CH471066 U52513
GenPept AAB40606 AAB95160 AAC63524 AAH01383 AAH04977 AAP35948 BAF83116 BAG59639 EAW50143 EAW50144
RNA Seq Atlas 3437

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca