Version 5.4
Homo sapiens Gene: IFIT1
Summary
InnateDB Gene IDBG-81960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFIT1
Gene Name interferon-induced protein with tetratricopeptide repeats 1
Synonyms C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1; IFNAI1; ISG56; P56; RNM561
Species Homo sapiens
Ensembl Gene ENSG00000185745
Encoded Proteins
IDBP-81962
interferon-induced protein with tetratricopeptide repeats 1
IDBP-587206
interferon-induced protein with tetratricopeptide repeats 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20386592
IFIT1 expression activates the IFN response during C. pneumoniae infection, mediated by intracellular nucleotide-sensing pattern recognition receptors (PRRs), which operate through a mechanism dependent on the bacterial type III secretion system (T3SS).
PMID 21642987
IFIT1 recognizes and directly binds to 5'-triphosphate RNA and functions as an innate inhibitor of viral replication and pathogenicity. (Demonstrated in murine model)
PMID 22745654
IFIT1 is an innate immune network bottleneck with the ability to suppress induction of TLR4 response genes in LPS-stimulated macrophages. (Demonstrated in mice)
PMID 24098121
IFIT1 binds mRNAs that lack 2â?²O methylation on the first ribose, thus inhibiting translation by impairing binding of eukaryotic translation initiation factors to 2â?²O-unmethylated RNA templates
PMID 24371270
IFIT1 binds with high affinity to the cap-proximal regions of cap0-mRNAs abrogating 48S complex formation in an in vitro reconstituted translation system.
Entrez Gene
Summary This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:89392546-89406486
Strand Forward strand
Band q23.31
Transcripts
ENST00000371804 ENSP00000360869
ENST00000546318 ENSP00000441968
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
Experimentally validated
Total 58 [view]
Protein-Protein 49 [view]
Protein-DNA 8 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0009615 response to virus
GO:0019060 intracellular transport of viral protein in host cell
GO:0019221 cytokine-mediated signaling pathway
GO:0032091 negative regulation of protein binding
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0050689 negative regulation of defense response to virus by host
GO:0051097 negative regulation of helicase activity
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0071357 cellular response to type I interferon
GO:0071360 cellular response to exogenous dsRNA
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.20315
RefSeq NM_001270927 NM_001270928 NM_001270929 NM_001270930 NM_001548
HUGO
OMIM
CCDS CCDS31243 CCDS59220
HPRD 00983
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca